SHARP Metabolomics Platform
Minimal Sample Requirement
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Comprehensive Metabolome Coverage
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High Accuracy & Precision
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Cutting-Edge Instrumentation
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WHAT IS SHARP METABOLOMICS PLATFORM?
The SHARP Metabolomics Platform (Small-Scale Highly Accurate and Reproducible Platform) is a cutting-edge metabolomics solution designed to deliver comprehensive, quantitative profiling of small molecule metabolites from minimal sample volumes. Built for researchers dealing with precious or limited biological material, such as rare clinical specimens, small animal models, or low-volume cell cultures.
SHARP combines rigorous analytical performance with practical flexibility, enabling researchers to analyze limited sample material without sacrificing data depth. By generating high-confidence quantitative results, we help support biological discovery and translational insights while integrating seamless downstream data analysis workflows. Whether your project focuses on basic metabolism, disease mechanisms, or therapeutic development, SHARP equips you with a powerful metabolomics solution designed around the realities of limited material and high scientific expectations.
HP-CIL VS Untargeted LC-MS?
Limited samples should never limit the scope of your research. Whether working with rare clinical biopsies, small animal models, organoids, or low-volume biofluids, researchers are often forced to make difficult trade-offs between conserving material and generating comprehensive data. SHARP was developed to eliminate that compromise.
Engineered specifically for minimal input workflows, the SHARP Metabolomics Platform delivers deep, quantitative metabolome coverage with the reproducibility and analytical confidence required for high-impact research. By maximizing sensitivity and precision at low sample volumes, SHARP enables full-scale biological insight — even when every microliter counts.
Discover Our Tiers Options
Basic SHARP Metabolomics Platform
Our Basic HP-CIL Metabolomics Platform is a single-channel analysis targeting either the amine/phenol or carboxyl submetabolome. It is ideal for focused studies, pilot experiments, or hypothesis-driven profiling of specific metabolite classes, and is priced at $95 per sample.
Elevated SHARP Metabolomics Platform
Our Elevated HP-CIL Metabolomics Platform provides dual-channel analysis covering amine/phenol and carboxyl submetabolomes. It is suited for studies requiring broader metabolome coverage and stronger quantitative insight, and is priced at $167 per sample.
Comprehensive SHARP Metabolomics Platform
Our Comprehensive HP-CIL Metabolomics Platform offers full four-channel coverage across amine/phenol, carboxyl, hydroxyl, and carbonyl submetabolomes. It is designed for projects requiring near-complete metabolome coverage and maximum analytical depth, and is priced at $316 per sample.
What are the capabilities of SHARP?
APPLICATIONS
Regardless of research focus or biological system, the HP-CIL Metabolomics Platform supports a wide range of applications by enabling access to over 1,000 metabolic pathways across diverse domains. Its broad metabolome coverage and robust quantification make it adaptable to both discovery-driven and hypothesis-led studies.
HP-CIL is widely applied in neuroscience, microbiology, plant and agricultural sciences, biomedical research, and pharmaceutical development, supporting investigations from basic biology to translational and clinical research. This flexibility allows researchers to explore complex metabolic networks, compare pathways across conditions, and generate biologically meaningful insights with confidence.
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Neuroscience
Characterize metabolic pathways involved in brain function, neurodegeneration, neuroinflammation, and neurological disorders with high quantitative confidence.
Microbiology & Microbiome Research
Profile microbial metabolism, host–microbe interactions, and pathway-level changes across complex biological matrices.
Plant and Agricultural Sciences
Investigate plant metabolism, stress responses, crop performance, and nutrient pathways to support agricultural and environmental research.
Biomedical and Pharmaceutical Research
Support disease biology studies, biomarker discovery, drug development, mechanism-of-action analysis, and translational research across preclinical and clinical models.
OUR WORKFLOW
Our process
Sample Reception
We start by receiving your raw samples, which can include a variety of biological materials such as unprocessed urine, plasma, serum, cell pellets, tissue, plant etc
Sample Aliquoting
Each sample is carefully aliquoted, depending on the number of submetabolomes (channels) required and whether a lipidome profiling analysis is also interested.
Sample Analysis
Basic HP-CIL Metabolomics Platform (one channel) is conducted.
Reporting and Consultation
Following the analysis, we will provide a detailed report of the findings and engage in a consultation to discuss the results and their implications.
What’s Included
Our Seemless End-End Process
We handle sample preparation, sample extraction, sample labeling, LC-MS analysis, data analysis, metabolite identification, and statistical analysis (volcano plots, pca, pls-da, heatmaps, etc.).
Your Choice
If you decide to pursue further analysis for a more comprehensive coverage, such as Elevated or Comprehensive Metabolomics Analysis and/or lipidome analysis, we seamlessly continue the process. The total cost will be determined based on the number of channels analyzed and the inclusion of lipidome analysis. Should you choose not to proceed with additional analysis, only the cost of the one channel analysis will be charged.
SAMPLE REQUIREMENT
KINDLY NOTE
- The sample amount in each cell is shown as “minimum amount / preferred amount.”
- Biofluids or tissues requiring special handling (e.g., dialysates, exosomes, needle biopsies) should be discussed with TMIC.
- Always measure or weigh samples during collection and send this information.
PUBLICATIONS
FAQ
What exactly is HP-CIL metabolomics?
HP-CIL stands for High-Performance Chemical Isotope Labeling. It is an LC-MS method that tags metabolites with special isotope labels so the instrument can detect them more clearly.
How is this different from normal untargeted metabolomics?
Regular untargeted metabolomics measures many metabolites at once, but sensitivity and quantification can vary.
HP-CIL improves this by:
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Using one-to-one internal standards for every labeled metabolite
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Reducing matrix effects and variability
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Giving more confident quantification
So you get broader, cleaner, and more reliable data.
How long does the analysis take?
Typical turnaround time is 3–6 weeks, depending on sample number, complexity, and whether pathway analysis is requested.
What if I only have a very small amount of sample? Can you still run metabolomics?
Yes, we can still analyze your samples. If you only have a very limited volume or mass, our SHARP platform is designed exactly for that. SHARP uses the same chemical isotope labeling technology as HP-CIL but is optimized for:
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Ultra-small sample volumes
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Low-input tissues or rare samples
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High-sensitivity detection even from minimal material
So even if you can only provide a few microliters or a tiny tissue amount, we can still generate high-quality metabolomics data.
ANALYZED SAMPLES
SERVICE PROJECTS
LC-MS INSTRUMENTS
CLIENTS
SPEAK TO AN EXPERT
Our experts will help you identify the right metabolomics platform that fit your study design, sample type, and discovery goals. In your free consultation, we’ll discuss your research objectives, outline tailored analytical strategies, and show how our precision LC–MS solutions can accelerate your path from data to discovery.
Funding Agencies and Partners
