April 2025 –The TMIC Li Node is excited to introduce the latest addition to our SHARP Platform: the SHARP (Small-Scale Highly Accurate and Reproducible Platform) Blood Metabolome Assay: SHARP-BMA, designed specifically for researchers working with small volumes of serum/plasma samples.
Following the successful launch of our SHARP Cell Metabolome Assay (SHARP-CMA), which provides high-quality metabolome analysis for researchers working with limited cell numbers, SHARP-SMA now expands our product line to include serum/plasma-based metabolomics. This addition strengthens our SHARP platform, offering researchers even greater flexibility in their metabolomics studies.
This cutting-edge service harnesses LC-MS technology for high-sensitivity metabolome profiling with minimal sample input. Powered by the Thermo Scientific Vanquish NEO LC and Orbitrap Exploris 240 Mass Spectrometer, it enables comprehensive metabolite profiling from small serum/plasma volumes. Despite the low sample size, the platform ensures enhanced peak pair detection and high-confidence metabolite identification across multiple submetabolome channels, including amine/phenol, carboxyl, hydroxyl, and carbonyl.
Blood samples are valuable yet often limited, making every drop precious. This can be due to factors like invasiveness of the collection process, the need for specific patient conditions like fasting, or difficulties drawing blood from patients with difficult veins. In pediatric, geriatric, or critically ill populations, these challenges are even more pronounced. SHARP-BMA is an ideal solution when sample volume is limited. With high sensitivity and robust performance, it enhances metabolomics analysis, providing precise quantification for blood-based studies and enabling deeper insights in biomarker discovery, clinical research, and precision medicine.
Key highlights include:
- Low Sample Input: Advanced Chemical Isotope Labeling LC-MS technology designed to analyze small volumes of serum/plasma with as few as 4 µL, making it ideal for studies where sample quantity is limited.
- Comprehensive Metabolome Coverage: Optimized separation and ionization enhance metabolite detection and high-confidence identification. Detect up to 750 metabolites and 1,000 metabolite candidates with the Basic SHARP-BMA, 1,150 metabolites and 2,300 metabolite candidates with the Elevated SHARP-BMA, and a further 1,400 metabolites and 5,000 metabolite candidates with the Comprehensive SHARP-BMA.
- High Accuracy and Precision: Unique “one to one” internal standard approach enables superior quantification.
- Cutting-Edge Instrumentation: Powered by the Thermo Scientific Vanquish NEO LC system integrated with the Orbitrap Exploris 240 Mass Spectrometer.
At TMIC Li Node, we remain committed to advancing metabolomics research by providing innovative and precise analytical tools that cater to the evolving needs of the scientific community. With the introduction of SHARP-BMA, we further strengthen our SHARP platform, empowering researchers with enhanced capabilities for blood-based metabolomics analysis.
If you would like to learn more about our new SHARP Blood Metabolome Assay: SHARP-BMA, please visit our service page or contact us.