Equipment

At the Li Node of The Metabolomics Innovation Centre, we are equipped with a comprehensive array of state-of-the-art metabolomic and lipidomic analysis instruments. Our facility includes advanced mass spectrometry systems and Ultra-High Performance Liquid Chromatography (UHPLC) technology, ensuring precision and accuracy in our analyses. Our dedicated team of scientists and technicians boasts extensive experience and is thoroughly trained in standard operating procedures, equipment maintenance, and quality assurance protocols. We are adept at handling diverse samples and have honed our skills in various experimental techniques to provide reliable and insightful results.

Please get in touch with us if you have any queries about selecting the right instrument or analysis type for your project. We are here to guide you in making the best choices for your research needs. Additionally, for a deeper understanding of our metabolomic analysis techniques, we invite you to click here for more detailed information.

Bruker Impact QToF MS – Dionex Ultimate3000 UHPLC

List of Major Equipment:

UHPLC – High Resolution Mass Spectrometry

  • Bruker Impact II QTOF with Thermo UHPLC
  • Bruker Impact II QTOF with Agilent UHPLC
  • Bruker Impact II with Thermo 2D-UHPLC
  • Agilent 6546 QTOF with UHPLC
  • Agilent 6546 QTOF with 2D-UHPLC
  • Thermo Orbitrap Exploris 240 with nano-UHPLC
  • Thermo Orbitrap Exploris 240 with micro-UHPLC
  • Thermo Orbitrap Exploris 240 with 2D-UHPLC

Tandem Quadrupole Mass Spectrometry

  • Waters Xevo Tandem Quadrupole MS

HPLC and UPLC

  • Agilent 1220 HPLC with fraction collector and fluorescence detector

Bruker Impact II QTOF features market-leading sensitivity with its dual ion funnel and IonBooster source, enabling the detection of even the lowest abundance compounds in complex matrices. Its dynamic range spans five orders of magnitude, ensuring comprehensive detection across a wide concentration range. With an enhanced TOF resolving power and mass accuracies typically less than 1 ppm, the Impact II delivers high-resolution data and precise mass measurements, crucial for accurate compound identification and characterization. With Full Sensitivity Resolution (FSR), the Impact II maintains full sensitivity without compromising resolution, ensuring in-depth analysis and detection of minute sample components. The Impact II’s robust hardware and innovative ion sources provide consistent performance with reduced sample pretreatment, ideal for high throughput applications.

Agilent 6546 QTOF offers over 5 orders of magnitude in dynamic range and a resolution of up to 60,000, allowing for the detection of both low-abundance compounds and high-concentration analytes with exceptional clarity, providing high resolution and dynamic range. It is capable of maintaining high resolution at acquisition rates up to 30Hz, this instrument ensures fast and thorough analyses, perfect for both targeted and untargeted studies. Built on Agilent’s proven technology, the 6546 QTOF is designed for robust performance with minimal downtime, ensuring consistent and dependable operation across numerous applications. 

Thermo Orbitrap Exploris 240 is optimized for everyday simplicity, delivering faster turnaround times from sample to result. This means you can achieve high-quality data quickly, allowing more time to focus on the biological relevance of your work rather than method optimization. Simultaneously, it delivers premium performance with the fast-scanning High-Field Orbitrap™ mass analyzer. This ensures high-resolution accurate-mass (HRAM) data, providing reliable and reproducible results. Designed with a compact footprint to conserve bench space, the Orbitrap Exploris 240 mass spectrometer is built for durability and robust performance. The advanced ion optics, including the S-lens and Advanced Active Beam Guide (AABG), ensure high ion transmission and reduced noise, contributing to the instrument’s outstanding sensitivity and reliability.

Waters Xevo Tandem Quadrupole MS features T-Wave™ and ScanWave™ Enabled Collision Cell Technology, which provide exceptional flexibility and analytical capabilities, supporting both quantitative and qualitative studies on a single platform. The High-Resolution Quadrupole Analyzers enable maximum resolution and transmission, preventing contamination of the main analyzers. The Waters Xevo TQ MS supports high-speed Multiple Reaction Monitoring (MRM) with enhanced full scan spectral acquisition modes, for comprehensive LC/MS/MS capabilities. Efficient ESI desolvation optimizes gas flow dynamics, supporting LC flow rates up to 2 mL/min and therefore ensuring high-quality data.

Agilent 1220 HPLC is an advanced liquid chromatography system designed to deliver top-tier performance, reliability, and efficiency. It delivers run-after-run reproducibility, ensuring the highest confidence in your results. With its precise and reliable solvent delivery system, it can achieve stable, virtually pulse-free solvent flow, essential for accurate and consistent analyses.  Featuring optimized optics and low-noise electronics, the variable wavelength detector lowers detection limits and expands application capabilities. The diode array detector ensures more confidence in the qualification and quantification of impurities, even at trace levels.

Bruker Impact II QTOF MS

Bruker Impact II QTOF MS

Funding Agencies and Partners